System Analysis of the Cadherin Adhesome
Previously, we successfully constructed the integrin adhesome, which is a database of all known components of integrin mediated adhesion and the interactions between them. We have gone on to analyze the adhesome network using systems biology approaches. We performed a similar literature based construction of a network of adherens junction components, we named the Cadhesome, and are in the process of analyzing it and comparing it to the integrin adhesome. The first version of our literature-based cadhesome was published in JCS in January 2013.