People

Group photo NUS Aug 2017

Dr. Zaidel-Bar – Principal Investigator

Dr. Ronen Zaidel-BarRonen Zaidel-Bar – Principal Investigator

His fascination with the molecular mechanics of cell adhesion and the cytoskeleton began as a graduate student at the Weizmann Institute of Science. With Prof. Benny Geiger as my mentor, he used live-cell fluorescence microscopy to study the assembly dynamics of cell-matrix adhesions, elucidating the roles of force and phosphorylation in their regulation. Most of his PhD was focused on molecular mechanisms pertaining to specific proteins, but toward the end they took a more holistic approach and introduced to the field the now well-accepted concept of the “integrin adhesome”.

Awarded an NIH Ruth L. Kirschstein National Research Service Award to pursue postdoctoral training at the University of Wisconsin-Madison, he continued his investigation of cell adhesion in the context of a developing embryo. Under the guidance of Prof. Jeff Hardin he harnessed the power of genetics and live-embryo imaging to elucidate the role of several novel cell-cell junction proteins and actin regulators in C. elegans. In parallel, he continued to explore the adhesome at the system level, including from an evolutionary perspective.

In 2010 he was offered the opportunity to lead an independent research group at the interdisciplinary Mechanobiology Institute (headed by Prof. Mike Sheetz), supported by a grant from the Singapore National Research Foundation (under the NRF fellowship program). In parallel he was also appointed as an assistant professor in the department of Biomedical Engineering, National University of Singapore. Combining his experience in both mammalian cell adhesion and C. elegans genetics his group exploits the natural synergy between the two to address key mechanobiological questions.

In the fall of 2017 Ronen moved back to Israel to become an Associate Professor in the department of Cell and Developmental Biology at the Tel-Aviv University School of Medicine, and to start a second research group.

Back to top »

Dr. Anat Nitzan, Lab Manager

Anat NitzanAnat did her PhD in the field of ophthalmology under the supervision of prof. Arieh Solomon, from the faculty of
medicine and Prof. Ari Barzilai, from the faculty of life sciences at Tel-Aviv University, Israel. Her research focused on
the analysis of cellular and molecular events associated with optic nerve degeneration and regeneration in a rat
model of optic nerve axotomy. After graduation she became prof. Solomon’s lab manager at the Goldcshleger Eye
Research Institute, Sheba Medical Center, Israel. There, she took part in a European funded project to develop a
drug for the prevention of retinal cell degeneration in Glaucoma using a novel eye implant. She then spent a year at
Sourasky Medical Center, as a researcher and lab manager for the Department of Ophthalmology. Seeking new challenges, she came back to Tel-Aviv University to join Prof. Zaidel-Bar’s lab as lab manager.

Back to top »

Dr. Anup Padmanabhan – Postdoc

Anup completed his B.Tech in Industrial Biotechnology from Anna University, India and carried out his masters at the Singapore-MIT Alliance program.  After his masters, he joined the Bioprocessing Technology Institute at Biopolis where he worked towards understanding stress-induced apoptosis in mammalian cells.

During this time he became interested in the phenomenon of cytokinesis.  Therefore for his Ph.D, he joined Prof. Mohan Balasubramanian‘s Cell Division Lab at Temasek Life Sciences Laboratory, where he worked on understanding the mechanisms regulating the positioning and assembling of actomyosin rings during cytokinesis in fission yeast.  The beauty in C.elegans embryo development attracted him to the Zaidel-Bar Lab.  Having developed a taste and technique for imaging during his graduate studies, he is now focusing his attention towards understanding the role of cell adhesion in cytokinesis during the development of C.elegans embryo.

Back to top »

Dr. Regha Kakkad – Research Associate

Regha did her Ph.D. from the Centre for Cellular and Molecular Biology, India. After this, she did postdoctoral research in the lab of Prof. Denise Barlow at the Center for Molecular Medicine, Vienna, where she worked on epigenetic modifications associated with imprinted genes. She then joined the lab of Prof. Constanze Bonifer at the University of Birmingham, UK, and studied the  effect of expression of leukaemia-associated oncoproteins in early hematopoiesis. This lead to an interest in the regulation of cell adhesion and migration and she joined Zaidel-Bar lab to pursue it further.

Regha Kakkad

Regha Kakkad

Back to top »

Dr. Priti Agarwal – Postdoc

priti_croppedPriti did her PhD in the area of genetics and developmental biology with  Dr. K. Subramaniam at Indian Institute of Technology Kanpur, India. Her graduate studies were focused on understanding meiosis: a specialized type of differentiation germ cells undergo to form mature gametes – oocytes and sperm, using C. elegans as a model organism. While studying the role of biochemical signals during germ cell development, she became interested in the biomechanical signals required for continuous formation of mature oocytes and sperm. This motivated her to analyze the biophysical features of the C. elegans germline and further, to explore how mechanical forces conjoin with biochemical signals to determine the structure and function of the germline. She joined Dr. Zaidel-Bar’s lab to achieve to this goal.

 

 

 

 

Back to top »

Kriti Sethi – Postdoc

kritiKriti developed an interest in fission yeast cytokinesis during a research project at Dr. Chris McInerny’s laboratory during her Master’s degree at University of Glasgow. With an interest in understanding how actomyosin ring contraction and division septum synthesis are coupled in fission yeast, she joined Prof Mohan Balasubramanian’s laboratory at Temasek Life Sciences Laboratory for her PhD studies. During this time she became interested in understanding how contractility is regulated and coordinated at a tissue-level. With this aim, she will be focussing on actomyosin contractility in the spermatheca at the Zaidel-Bar lab.

 

 

 

 

 

 

 

Back to top »

Shinjini Ray – Graduate student

ShinjiniShinjini pursued her master’s by research from Tata Institute of Fundamental Research, Mumbai, India in Dr. Mahendra Sonawane’s lab. In his lab, she looked at the regulation of cell shape pattern by signaling pathways in the zebrafish larval finfold, an evolutionarily old unpaired appendage. She looked at the role of crosstalk between Wnt and TGFβ signaling pathways in regulation of cell shape during development of the finfold. During her master’s program, she developed an interest for cell and developmental biology. She was further interested in studying the mechanical aspects of these processes which lead her to join the mechanobiology institute for her PhD where she joined Dr. Ronen Zaidel Bar’s lab.

 

 

Back to top »

Alumni

Dr. Cristina Bertocchi – Postdoc.

Aishwarya Srinivasan – Research assistant.

 Thang Doan – Research assistant

Dr. Yemima Budirahardja – postdoc

Yemima

Guo Zhenhuan (Gary) – Research Assistant

Wu Yao – Graduate student

Pei Yi TAN – Graduate student

Megha Vaman Rao

megha

Wei Yung DING

Wei Yung

Shuangshuang DU – Undergraduate intern

Shuangshuang Du

Back to top »